Improve brain memory, magnesium L-threonate has been approved by the European Union as a new food!

In October 2024, the European Commission authorized AIDP's magnesium L-threonate to be placed on the market as a novel food and revised Implementing Regulation (EU) 2017/2470. Source: eur-lex
 

Magnesium L-threonate becomes a new food

According to the European Commission announcement, the chemical name of magnesium L-threonate is magnesium (2R,3S)-2,3,4-trihydroxybutyrate monohydrate, and its common name is magnesium L-threonate. This new type of food is produced using chemical synthesis methods. It appears as white powder and has a maximum consumption of 250 mg/day. This supplement is intended for adults (excluding pregnant and breastfeeding women).
Source: eur-lex
 

The European Commission states that magnesium L-threonate should be considered a source of magnesium, bringing more bioavailable options to magnesium supplements. The Food Safety Administration evaluated the safety of L-magnesium threonate new food based on rat bioavailability studies, in vitro bacterial recovery mutation tests, in vivo micronucleus tests, and randomized placebo-controlled human studies. The results showed that L-threonate magnesium Magnesium sugarate is a source of magnesium with established safety and bioavailability when added to food supplements for nutritional purposes.
 

Magnesium L-threonate, higher absorption and retention

Magnesium L-threonate, higher absorption and retention

Magnesium (Mg) is the second most abundant mineral in cells and is a cofactor for more than 300 enzymatic reactions. Therefore, magnesium is also an essential nutrient for various metabolic functions in the body. It plays an important role in cellular energy production, protein production, and genes. It plays an important role in regulating, maintaining the normal function of bones and teeth. Magnesium can not only activate the activities of various enzymes in the body, but also regulate nerve function, maintain the stability of nucleic acid structures, regulate body temperature, affect people's emotions, and participate in almost all metabolic processes of the human body.

Magnesium is abundant in the food supply and is found in grains, cereals and dark leafy foods such as spinach and cabbage.

The most common added ingredients in magnesium supplements include magnesium glycinate, magnesium L-threonate, magnesium malate, magnesium taurate, magnesium oxide, magnesium chloride/magnesium lactate, magnesium citrate, magnesium sulfate, etc. Among them, magnesium L-threonate is a magnesium compound with high bioavailability.
Source: pixabay
 

In 2010, MIT scientists published an article in the journal Neuron, reporting that they had discovered a magnesium compound called L-magnesium threonate (Magtein®), which can effectively convert magnesium into delivered to brain cells. Research shows that magnesium L-threonate is better absorbed and retained compared to other sources of magnesium, such as chloride, citrate, glycinate, and gluconate.
 

Magnesium L-threonate benefits

As a new bioavailable magnesium compound, magnesium L-threonate is increasingly becoming known for its potential to improve cognitive function and enhance memory. Numerous studies have shown that magnesium L-threonate can effectively transport magnesium into neuronal cells across the blood-brain barrier, thereby enhancing neuroplasticity, improving memory and cognitive abilities, and reducing anxiety and stress.

Enhanced memory

In rodent model, studies have found that after one month of magnesium L-threonate supplementation, magnesium concentrations in the brains of young and old rats increased, and memory and learning abilities were significantly improved. Magnesium L-threonate also improved memory recovery in aged rats. Magnesium L-threonate supplementation does not affect body weight, exercise capacity, or water and food intake. The mechanism of action of magnesium L-threonate on cognitive function may be through activation of NMDA receptors, which increases synaptic density and improves memory.

Another experiment found that long-term oral administration of magnesium L-threonate can prevent and restore short-term memory (STM) and hippocampal long-term potentiation (LTP) deficits in hippocampal CA3-CA1 synapses caused by neurological injury (SNI). Furthermore, prophylactic long-term oral administration of magnesium L-threonate blocks the upregulation of TNF-α in the hippocampus, which has been shown to be critical for memory deficits. Oral administration of magnesium L-threonate may be a simple and effective way to improve memory deficits.

Improved sleep quality

One study found that subjects who supplemented with magnesium L-threonate experienced improved sleep quality, as well as improved mental clarity and physical activity during the day. It’s worth noting that the sleep benefits of magnesium L-threonate are more about improving deep sleep quality and mental alertness upon waking than helping people fall asleep faster.

Improved cognition

Hypoxia inhibits the entry of glutamate, a major brain neurotransmitter closely related to cognitive function, into brain cells, and the initial cellular response to cortical hypoxia is dependent on glutamate. Magnesium L-threonate increases magnesium ion concentrations in the brain and improves cognitive function. Studies have found that magnesium L-threonate can regulate the expression of glutamate transporter EAAT4, and has a positive effect on neuron survival and reducing cerebral infarction in zebrafish after hypoxia.

Related products of L-Magnesium threonate

Magnesium has always been an undervalued nutrient in the daily diet, but with the growing demand for nutritional supplements and functional foods, the market for magnesium and magnesium L-threonate is gaining more and more attention. Currently, magnesium L-threonate is mainly used in capsules, ready-to-drink beverages, snack bars, gummies and other products.

BESTVITE brand has launched a capsule containing magnesium L-threonate, which can easily cross the blood-brain barrier and protect brain health.

Source: amazon

NATURAL STACKS lemonade drink contains magnesium L-threonate and magnesium glycinate, which are beneficial for relaxation and brain health.

Source: amazon
 

Life extension has launched a tropical-flavored solid beverage of magnesium L-threonate, which can improve the body's cognition and memory.

Source: life extension europe

Magtein - Magnesium L-Threonate Adult Gummies can cross the blood-brain barrier and play a role in strengthening the brain, replenishing concentration, and enhancing memory and cognitive function. The longer you take it, the better the effect.

Source: magceutics
[1]https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32024R2694&qid=1733346877222

[2]https://pmc.ncbi.nlm.nih.gov/articles/PMC9786204/

[3]https://pubmed.ncbi.nlm.nih.gov/24077207/

[4]<SPINS releases 2024 trend report | Which health categories are growing rapidly? Which functional ingredients have potential?>

[5]https://pmc.ncbi.nlm.nih.gov/articles/PMC11381753/#sec5