GABA, a natural anti-aging factor

Gamma aminobutyric acid (GABA), also known as γ-aminobutyric acid, 4-aminobutyric acid, and aminobutyric acid, is a non-protein amino acid widely distributed in animals and plants. It plays an irreplaceable role in regulating the life activities of organisms.

Gamma Aminobutyric Acid

The molecular formula of gamma aminobutyric acid (GABA) is C4H9NO2, with a molecular weight of 103.1. It is white flake or needle-shaped crystals, highly soluble in water, slightly soluble in hot ethanol, and has a melting point of 202°C. At present, GABA has been extracted from rice, mulberry leaves, potatoes, tea and other plants, and has been used in industry, food, cosmetics, medicine and other fields.

Gamma aminobutyric acid(GABA) is an important inhibitory neurotransmitter in the central system of mammals. Current research has found that nearly 50% of inhibitory neurotransmissions use GABA as a mediator; in animals, the physiological activity of GABA is mainly reflected in In the following aspects:

①Lower blood pressure;

②Calming and calming, anti-anxiety;

③Improve brain vitality;

④Reduce blood ammonia and improve liver and kidney function.

The fermented gamma aminobutyric acid(GABA) provided by SHAANXI PYSON uses advanced microbial fermentation technology to produce GABA. This method can produce high-purity GABA while ensuring the natural and healthy properties of the product.

1. Soothe nerves and relax wrinkles

Gamma aminobutyric acid(GABA) has a small molecular weight, penetrates the skin and binds to GABA_A receptors in skin cells, and activates GABA_A receptors, causing the opening of chloride ion channels, which can increase the permeability of cell membranes to chloride ions and allow chloride ions to flow into the nerves. In cells, it causes hyperpolarization of cell membranes, inhibits the excitement of nerve cells, thereby relieving excessive nervous tension, making people feel calm and relaxed, fundamentally calming nerves, achieving the effects of relaxation, anti-anxiety, and promoting sleep (orally administered to improve human sleep ).

At the same time, after the neuron cells are inhibited, the excitement of muscle cell contraction is effectively slowed down, allowing the wrinkle muscles to relax, thereby achieving the effect of reducing fine lines and diluting wrinkles.

2. Promote cell regeneration and repair damaged skin

GABA can promote the proliferation of epidermal cells and the production of keratinocyte tegument proteins, repair the stratum corneum barrier, and reduce skin roughness. In addition, GABA can also stimulate cells to secrete more glutathione, scavenge free radicals, and reduce damage to the skin caused by harmful factors such as ultraviolet rays.

3. Promote HA and collagen synthesis

As we age, the GABA content in the skin decreases, causing the neuronal cells to not relax for a long time, thus forming wrinkles. GABA can activate fibroblasts, promote the synthesis of type I collagen and hyaluronic acid, while reducing the activity of metalloproteinases such as MMP, slowing down the degradation of collagen, increasing endogenous hyaluronic acid, thereby improving skin elasticity and water retention, reducing wrinkle.

4. Repair and soothing effects

The application of GABA in cosmetics is not limited to anti-aging, but also includes repairing and soothing effects; it can inhibit the irritation caused by certain chemical components, and can be combined with a variety of active substances to improve the efficacy, such as being used as a skin care conditioner when combined with linolenic acid. Compatible with vitamin E, it has a synergistic anti-aging effect and can effectively enhance the function of hair growth aid.

SHAANXI PYSON has studied the human efficacy of eye cream containing 0.3% aminobutyric acid (GABA). Test method: The subjects were randomly divided into two groups, with 15 in each group. One group applied the test article, and the other group applied the control article, once in the morning and evening. The wrinkles of the same parts of the volunteers were evaluated before application and 2 weeks, 4 weeks, 8 weeks, and 12 weeks after application.

As shown in the figure, after 8 weeks of using an eye cream containing 0.3% Gamma aminobutyric acid(GABA), the depth of wrinkles was significantly reduced, by 12% at 8 weeks and by approximately 17% after 12 weeks.

Summary: As a natural anti-aging factor, GABA has broad application prospects in cosmetics. Its multi-faceted efficacy and high safety make it an ideal ingredient for anti-aging cosmetics. SHAANXI PYSON's technological innovation and product development not only promote the application of GABA in cosmetics, but also provide consumers with more scientific and effective skin care options; with the continuous deepening of research on GABA, its application in cosmetics and food fields The application prospects will be broader.

References:

[1] Liu Xiaojuan, Liu Haiyang, Li Ming, et al. Analysis of physiological effects and applications of γ-aminobutyric acid [J]. China Food Industry, 2021, (08): 20-21.

[2] Li Yao, Wang Lei, Sun Xin, et al. Research progress on the biological functions of γ-aminobutyric acid [J]. Agriculture and Technology, 2024, 44(10): 12-14.

[3] Zhou Junping, Xu Yujuan, Wen Jing, et al. Research progress on γ-aminobutyric acid (GABA) [J]. Food Industry Science and Technology, 2024, 45(05): 393-401.

[4] Jin Yingchun. Using silkworms and nematodes as models to study the anti-aging and lipid-lowering effects of γ-aminobutyric acid [D]. Jiangsu University of Science and Technology, 2022.